Seminar: Robert Passier

Modeling human heart disease in a dish

24 November 2015 10:00 hrs. - 11:00 hrs.
Demozaal Pathology, route 828
Modeling human heart disease in a dish

Prof. Robert Pasier, University of Twente, the Netherlands


Dirk Lefeber, Dept. of Neurology, Radboudumc

24-11-2015 10:00:0024-11-2015 11:00:00Europe/AmsterdamModeling human heart disease in a dish Demozaal Pathology, route

Remarks / more information:

Please be invited to this presentation on stem cell technology to model human (genetic) disease with future developments in organ-on-a-chip.

Location: Demozaal Pathologie 3e verd. P-West route 828 (please be quiet as you pass the department of Pathology).

Modeling human heart disease in a dish.

Prof. Robert Passier (University of Twente)

undefinedundefinedSince the groundbreaking discovery of Shinya Yamanaka to generate pluripotent stem cells from adult human somatic cells, many researchers speculated about the enormous potential of these induced pluripotent stem (iPS) cells in the fields of regenerative medicine, disease modeling and drug screening and toxicity. Pluripotent stem cells can be differentiated to anycell type of the human body. Here, I will discuss the potential of human iPS cells for cardiovascular applications. Patient-derived iPS cells are being used for studying cardiovascular disease in order to increase our knowledge on the disease mechanism and to identify new druggable targets. In addition, recently developed procedures to generate, expand and purify cardiac subtype populations such as ventricular, atrial and pacemaker cardiomyocytes and vascular cells will facilitate development of advanced functional in vitro assays and will advance the fields of regenerative medicine and tissue engineering. The latest developments and future prospects will be discussed.”


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