Seminar: Robert Schneider, theme Cancer development and immune defence

Novel players in chromatin

8 September 2015 14:00 hrs. - 15:00 hrs.
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Novel players in chromatin

Robert Schneider, IGBMC, Strasbourg, France


Michiel Vermeulen, Dept. of Molecular Biology, Radboudumc

08-09-2015 14:00:0008-09-2015 15:00:00Europe/AmsterdamNovel players in chromatin Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route

Remarks / more information:

undefinedOur focus is on medical epigenetics, with a long-term aim to apply mechanistic insights towards therapy, e.g. by identifying novel therapeutic targets or new diagnostic markers.. We are currently identifying and studying new histone modifications. We are deciphering how these modifications are inherited, how they regulate gene expression/chromatin dynamics, and in particular their role in disease processes such as cancer. Whilst it is still under discussion if histone modifications form a true "code", it has now been established that changes of histone modifications (and of their ”readers”) are involved in the regulation of all genes and as such can initiate disease processes. Therefore the significance of studying chromatin modifications extends far beyond the field of chromatin research and has clear medical relevance.  

Key Publications

  • Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription. Elife; 3:e01632, 2014
  • Regulation of transcription through acetylation of H3K122 on the lateral surface of the histone octamer. Cell; 152:859-72, 2013.
  • Targeting histone modifications-epigenetics in cancer. Curr Opin Cell Biol; 25:184-9, 2013. 

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