Seminar: Stefan Linder

Regulation of actomyosin contractility at macrophage podosomes

Date:
8 March 2017 12:00 hrs. - 13:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Regulation of actomyosin contractility at macrophage podosomes
Speaker(s):

Stefan Linder, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany

Host(s):

Alessandra Cambi, Dept. of Cell Biology, RIMLS

08-03-2017 12:00:0008-03-2017 13:00:00Europe/AmsterdamRegulation of actomyosin contractility at macrophage podosomes Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

undefinedPodosomes are the primary adhesive, mechanosensing and degradative organelles of macrophages. This talk will provide an overview on podosome structure and function. It will also focus on the regulation of actomyosin contractility at podosomes and the interplay between the different activities of these multipurpose organelles.

Flyer

 

 

 

 

Key Publications

  • Metalloproteinase MT1-MMP islets act as memory devices for podosome reemergence. J. Cell Biol. 213, 109-125, 2016
  • The formins FHOD1 and INF2 regulate inter- and intra- structural contractility of podosomes. J Cell Sci; 129:298-313, 2016
  • ER-coordinated activities of Rab22a and Rab5a drive endosomal compaction and intracellular processing of Borrelia burgdorferi by macrophages. Cell Reports; 12, 1-15, 2015


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