Seminar: Vera van Noort

Role of kinase signaling in Ebola virus disease

Date:
23 November 2016 11:00 hrs. - 12:00 hrs.
Location:
Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289
Title:
Role of kinase signaling in Ebola virus disease
Speaker(s):

Vera van Noort, Centre of Microbial and Plant Genetics, KU Leuven, Belgium

Host(s):

Martijn Huynen, Comparative Genomics, CMBI, RIMLS

23-11-2016 11:00:0023-11-2016 12:00:00Europe/AmsterdamRole of kinase signaling in Ebola virus disease Figdor Lecture Theatre, 8th floor RIMLS Building, Geert Grooteplein 26-28, route 289Rimlsrimls@radboudumc.nl

Remarks / more information:

undefinedThe recent outbreak of Ebola virus disease (EVD) resulted in a large number of human deaths. Due to this devastation, the Ebola virus has attracted renewed interest as model for virus evolution. Recent literature on Ebola virus (EBOV) has  contributed substantially to our understanding of the underlying genetics and its scope with reference to the 2014 outbreak. Over 500 genomes of Ebola have been sequenced to unravel genetic changes and dynamics, but no study yet, has focused on the conservation patterns of EBOV proteins. In order to gain more insight into the molecular biology of EVD we identified evolutionary conserved residues and assign functions to them. We do this by i) collecting known and predicting novel post-translational modifications on EBOV proteins ii) mapping conserved residues on to three-dimensional structures iii) collect protein-protein interactions between virus and host proteins iv) find motifs that may mediate protein-protein interactions and v) map conserved and modified residues to interaction interfaces.  Our results suggest the presence of novel post-translational modifications in EBOV proteins and their role in the modulation of protein functions and protein interactions. Moreover, on the basis of the presence of ATM recognition motifs in all EBOV proteins we postulate a role of DNA damage response pathways and ATM kinase in EVD.

Key Publications:  

  • Evolutionary conservation of Ebola virus proteins predicts important functions at residue level. Bioinformatics. 2016 
  • Integration of multi-omics data of a genome-reduced bacterium: Prevalence of post-transcriptional regulation and its correlation with protein abundances. Nucleic Acids Res. 2016 
  • Novel drug candidates for the treatment of metastatic colorectal cancer through global inverse gene-expression profiling. Cancer Res. 2014  
  • Evolution and functional cross-talk of protein post-translational modifications. Mol Syst Biol. 2013 

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