Astmafonds fellowship for Jeroen Langereis

Langereis , Jeroen

Dr.Jeroen Langereis (laboratory of pediatric infectious diseases) received a 40k€ grant for his research on non-typeable Haemophilus influenzae (NTHi) and the development of chronic obstructive pulmonary disease (COPD). 

COPD is a progressive disease which causes a huge healthcare burden with almost 24 billion spend every year in the USA alone. COPD progression shows a clear relation with colonization of the lungs with NTHi, a bacterium that usually colonized the nasopharynx.

Especially neutrophilic granulocytes, part of the innate immune system, are recruited to the lungs of COPD patients during infections, aimed to clear the pathogen. However, NTHi is resistant to neutrophil-mediated killing, which enables prolonged colonization of the lungs and increases disease progression and severity.

With this astmafonds fellowship, dr. Jeroen Langereis will investigate how the shape of NTHi prevents killing by neutrophilic granulocytes. Knowing the mechanisms could lead to the identification of novel anti-bacterial therapies. This research will be conducted in the lab of Prof. Jeffrey Weiser in Philadelphia, USA.  Logo Astma fonds

 


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