Cell Reports publication

Lee , Van Der Robin

In a recent publication in Cell Reports, Robin van der Lee (Centre for Molecular and Biomolecular Informatics, group of Martijn Huynen) and colleagues from the MRC Laboratory of Molecular Biology in Cambridge (group of M. Madan Babu) revealed an important role for intrinsically disordered protein regions in determining cellular protein half-life.

"Cellular function requires precise adjustment of protein concentrations. Protein degradation is the endpoint of gene expression and thus a primary determinant of protein abundance. Van der Lee et al. report that the length and number of disordered regions in substrates are two fundamental genetic and evolvable parameters that affect protein half-life and hence protein abundance in cells. They suggest that natural variation in disordered segments of proteins may serve as an underappreciated source of genetic variation with important phenotypic consequences."

Van der Lee et al., Intrinsically Disordered Segments Affect Protein Half-Life in the Cell and during Evolution,        Cell Reports 

Read more about intrinsically disordered proteins in this recent review: Van der Lee et al., Classification of Intrinsically Disordered Regions and Proteins, Chemical Reviews 114, 6589-6631, 2014. 


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