Crippled parasite as new malaria vaccine

Sauerwein Robert

Researchers from the Dept. of Medical Microbiology in collaboration with Leiden University Medical Centre (LUMC) have managed to genetically weaken mouse and human malaria parasites. The parasites completely lose their pathogenicity, but still initiate a full protective immune response in mice. These results are described in the online journal eLife "The experimental malaria vaccine is so promising that we can test it on humans."

Publication:
eLife - "A genetically attenuated malaria vaccine candidate base don P. falciparum b9/slarp gene-deficient sporozoites", Ben C.L. van Schaijk, Ivo H.J. Ploemen, Takeshi Annoura, Martijn W. Vos, Lander Foquet, Geert-Jan van Gemert, Severine Chevalley-Maurel, Marga van de Vegte-Bolmer, Mohammed Sajid, Jean‐Francois Franetich, Audrey Lorthiois, Geert Leroux-Roels, Philip Meuleman, Cornelus C. Hermsen, Dominique Mazier, Stephen L. Hoffman, Chris J. Janse, Shahid M. Khan, Robert W. Sauerwein, eLife, 19 november 2014, http://elifesciences.org/content/early/2014/11/19/eLife.03582

Photo: Prof. Robert Sauerwein, Dept. of Medical Microbiology, Radboudumc


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