Four Vidi grants for NCMLS researchers

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Four experienced researchers in the NCMLS have been awarded prestigious NWO-Vidi grants, each 800.000 Euros, to develop their own innovative lines of research. Vidi is part of Innovational Research Incentives Scheme from the Netherlands Organisation for Scientific Research (NWO). Vidi is aimed at outstanding researchers who have carried out their doctorates and several years of successful research. NWO selected the winners based on the quality of the researcher, the innovative nature of the research, the expected scientific impact of the research proposal and opportunities for knowledge utilization. In the Netherlands, a total of 86 projects were awarded of which 10 went to the Radboud University and Radboud University Nijmegen Medicial Centre. Four researchers are affiliated with the NCMLS institute. The NCMLS management wishes all winners every success in their projects.

Kamminga Leonie

Leonie Kamminga,
Department of Molecular Biology
Epigenetic regulation of cellular identity
Early development of multi-cellular organisms is a highly dynamic process requiring an exquisitely tight control over establishment and maintenance of cellular identity. This is essential for proper development and functioning of the organism. In this project the underlying mechanisms of tissue specification and maintenance will be studied.

Lefeber Dirk

Dirk Lefeber, Department of Neurology
Unraveling a unique sugar layer in human brain and muscle
Defective glycosylation of a unique and unsolved glycan in muscle and brain results in severe congenital muscular dystrophies. In a novel disease concept, we found already six defects in the regulatory pathways that supply the sugar building blocks for glycosylation. In this project, I will perform deep mechanistic studies of sugar metabolism by high-resolution mass spectrometry in novel well defined knock-out cells using available TALEN technology.

Hendrik , Marks

Hendrik Marks, Department of Molecular Biology
Understanding Embryonic Stem Cells
Embryonic Stem Cells (ESCs) are unique cells as they can differentiate to all specialized cell types present in an organism, but they are also able to self-renew without specialization. I will use state-of-the-art sequencing and proteome platforms, where feasible at single cell level, to comprehensively dissect the regulatory mechanisms in ESCs to understand these features.

Mulder, Klaas

Klaas Mulder, Department of Molecular Developmental Biology
Understanding how genes work together
External features such as our height, but also our sensitivity to diseases are determined by cooperating hereditary factors (genes). This project will elucidate which genes work together during the monthly renewal of the epidermis and what goes wrong in disease.

 


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