Joost te Riet has been awarded a Veni Grant

Riet, Joost te

In the proposed project entitled "Mechanotransduction at the immunological synapse" Joost te Riet (Department of Tumor Immunology) aims to unravel how ALCAM-CD6 interactions mechanically stabilize the immunological synapse (IS) between dendritic cells and T cells under physical stress.

Therefore, he will exploit a novel microscope that combines atomic force with confocal microscopy allowing him to study these processes at the IS in living cells via simultaneous live imaging and force manipulation.

His project will highlight the importance of mechanotransduction in immune cell stimulation and will pioneer the application of a novel hybrid microscope, thus developing areas of mutual interest for immunologists, cell biologists and biophysicists.

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