Malaria publication in PNAS

mug pnas

This week, the group of Robert Sauerwein (Department of Medical Microbiology) published a paper in Proc Natl Acad Sci USA.

In this paper, they show that immunization of human volunteers against P. falciparum malaria by chloroquine prophylaxis and sporozoites does not protect against a challenge with blood-stage parasites. Hereby, they demonstrate that protection in this highly efficient model is mediated by immunity against pre-erythrocytic stages. These findings support a continued focus on vaccine-development towards pre-erythrocytic stages, more particularly whole sporozoite approaches.


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