MEERVOUD grant for Jo H. Zhou

Zhou, Jo

Dr. Jo H. Zhou in Molecular Developmental Biology Department has been awarded the MEERVOUD grant by NWO-ALW. The title of her granted research is, 'Regulatory gene network in epidermal development'. Epidermis is a stratified epithelium that serves as a physical barrier for the organism. Epidermal stratification is dependent on proper control of proliferation and differentiation of keratinocytes localized in the basal layer of the epidermis. The transcription factor p63 is a master regulator of epithelial development, and it is important for both proliferation and differentiation of keratinocytes. The aim of this awarded research is to identify the p63-regulated gene network and epigenetic state during differentiation of keratinocytes established from normal individuals as well as from patients with p63 mutations. The outcome of this project is expected to provide insights of p63-mediated trancriptional regulation during differentiation in the epidermis. The p63-regulated gene network discovered in this study will also facilitate future genetic studies and therapeutic development for skin diseases.

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