NephroTube Crack-it Challenge awarded to Pharmacology-Toxicology

Wilmer , Martijn

The NC3Rs awarded Martijn Wilmer and Roos Masereeuw from the department of Pharmacology-Toxicology with £99,323 to conduct a proof of concept study in the NephroTube Crack-it Challenge. The goal of the NephroTube Challenge is to develop a microfluidic renal system that supports drug development by decreasing late attrition of compounds due to nephrotoxicity. In a consortium with Mimetas BV and the Swiss FHNW, they will develop a kidney-on-a-chip by combining the human renal cell line ciPTEC with the microfluidic device Organoplate, which will be used to detect renal tubular injury observed in drug-induced nephrotoxicity. Improved prediction of nephrotoxicity in early stages of drug development will help to reduce and/or refine animal experiments. This requires high-throughput screening of renal transport function and detection of nephrotoxicity upon compound exposure in a human cell-based platform.

The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) is a UK-based independent scientific organisation funding innovation and technological developments that replace or reduce the need for animals in research and testing. Funded by industrial sponsors, they designed the Crack-it Challenge, to support the development of new 3Rs technologies and approaches that will improve business processes or lead to new marketable products.Masereeuw, Roos


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