Poster prizes for genetics

NF2012_poster prize

During the New Frontiers symposium, a jury of 12 members selected the best three posters from more than 45. The jury scored in a number of categories including scientific merit, originality and style. The winners are Jeroen de Baaij, Kirsten Renkema and Bilge San. The three winners each receive a certificate and 100 Euros. Below the three winners are photographed with Jim Lupski, Hans Bloemendal & Rene Bindels.





Jeroen de Baaij, PhD student

Title:Elucidation of the distal convoluted tubule transcriptome identifies new candidate genes involved in renal magnesium handling

Authors:Jeroen H.F. de Baaij1, Marian J. Groot-Koerkamp2, Femke van Zeeland1, Hans Meijer1, Frank C.P. Holstege2, René J. M. Bindels1 and Joost G. J. Hoenderop1.

Affiliations:1Department of Physiology, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Centre The Netherlands. 2 Molecular Cancer Research, UMC Utrecht, The Netherlands

Conclusion: By elucidating the Mg2+-sensitive DCT transcriptome new candidate genes in renal Mg2+ handling have been identified.

Kirsten Renkema, Postdoc

Title: Gain-of-glycosylation in integrin α3 causes lung disease and nephrotic syndrome

Authors:Nayia Nicolaou1*, Coert Margadant2*, Sietske H. Kevelam1, Marc R. Lilien3, Michiel J.S. Oosterveld3, Maaike Kreft2, Albertien M. van Eerde1, Rolph Pfundt4, Paulien A. Terhal1, Bert van der Zwaag1, Norman Sachs2, Roel Goldschmeding5, Nine V.A.M. Knoers1, Kirsten Y. Renkema1#, A. Sonnenberg2#.

Affiliations:1Department of Medical Genetics, University Medical Center Utrecht, Utrecht; 2Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam; 3Department of Pediatric Nephrology, Wilhelmina Children's Hospital, University Medical Center Utrecht; 4Department of Human Genetics, Radboud University Nijmegen Medical Centre, Nijmegen; 5Department of Pathology, University Medical Center Utrecht; *#equal contribution.

Conclusion:These findings uncover a gain-of-glycosylation mutation in theITGA3gene that prevents the biosynthesis of functional integrin α3β1, causing a fatal multi-organ disorder.ITGA3gene screening was added to the DNA diagnostics toolbox, having important consequences for genetic counseling of patients and their relatives. Published in J Clin Invest. 2012 Dec 3;122(12):4375-87.

Bilge San, PhD student

Title:The loss ofezh2affects tissue maintenance in somatic and germ cells in zebrafish

Authors:Bilge San1, Peter van Maurik2, Nadine Wittkopp2, Marjo den Broeder2, Anne Lagendijk2, Emily Noel2, Federico Tessadori2, Jeroen Bakkers2, Renè F Ketting2, Leonie M Kamminga1.

Affiliations:NCMLS Molecular Biology Dept.1 and Hubrecht Institute2, The Netherlands

Conclusion:Our findings suggest that the lack ofezh2in zebrafish embryos causes defects in maintaining tissue identity in heart, gut and germ cells. Our future plans include the further analysis of these phenotypes using molecular and epigenetic techniques.

NF2012_poster prize_lupski

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