Publication in Acta Neuropathologica for Anneke Navis

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Anneke Navis, Dept. of Pathology, theme Nanomedicine published in Acta Neuropathologica a novel mutation in the MET gene which results in an auto-active, intracellular variant of this oncogene. Cancer cells expressing this truncated protein are not affected by therapeutic antibodies, but do respond to small molecule inhibitors making it to an important diagnostic biomarker.

Navis AC, van Lith SA, van Duijnhoven SM, de Pooter M, Yetkin-Arik B, Wesseling P, Hendriks WJ, Venselaar H, Timmer M, van Cleef P, van Bergen En Henegouwen P, Best MG, Wurdinger TD, Tops BB, Leenders WP. Identification of a novel MET mutation in high-grade glioma resulting in an auto-active intracellular protein. Acta Neuropathol. 2015 Apr 11. [Epub ahead of print]


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