Department of medical microbiology receives two ESMID grants

Rij, Ronald van

Eveline Snelders and Ronald van Rij, (dept of Medical Microbiology) both received an ESCMID Research Grant 2011 from the European Society of Clinical Microbiology and Infectious Disease. These grants help young and excellent investigators to pursue groundbreaking research in the fields of clinical microbiology and infectious diseases.

Eveline Snelders (Mycology) will use the grant to explore the function of TR as an azole resistance mechanism in human and plant pathogenic fungi . Different variants of tandem repeats (TR) in the promoter region of the Cyp51A gene (the target gene of azoles) have emerged in clinical Aspergillus fumigatus isolates in the Netherlands and are related to azole resistance. Continued azole pressure in the environment may cause multiple resistance mechanisms to emerge in A. fumigatus. This may have major consequences for the health risk assessment of the use of azole fungicides.

The research group of Ronald van Rij (Virology) will screen libraries of small molecules for compounds with antiviral activity against Dengue virus (DENV). Dengue virus a member of the Flaviviridae family, is the most important human arthropod-borne virus, which causes severe, sometimes fatal disease. Each year, DENV infects an estimated 50 million people. The incidence of DENV infections has grown dramatically in recent years and at present 40% of the world's population is at risk. Despite the enormous impact of DENV infections on public health, there is currently no licensed vaccine or specific treatment available.

Photo: Ronald van Rij

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