John van Dam and Martijn Huynen unravel the evolutionary origin of the IFT complex.

Huijnen, Martijn

Dam van, JohnJohn van Dam (right) and Martijn Huynen (left), from the department of CMBI unravel the evolutionary origin of the IFT complex.

 

 

 

 

 

John van Dam, Martijn Huynen from the department of CMBI and collaborators from the Universities of Cambridge and of California show that the Interflagellar Transport (IFT) complex, which transports cargo up and down the cilium, originated from COP I, a complex involved in cellular vesicle transport. By comparative genome analyses they have shown that the order in which the biochemically defined subcomplexes of the IFT arose during evolution, is reversed in the species from which they are lost, displaying a "a last in first out" mode of evolution. The evolutionary link between the IFT and COPI, and the evolutionary modularity of the IFT subcomplexes provide a framework against which we can interpret how mutations in IFT proteins lead to ciliopathies.

van Dam TJ, Townsend MJ, Turk M, Schlessinger A, Sali A, Field MC, Huynen MA. Evolution of modular intraflagellar transport from a coatomer-like progenitor PNAS April 8, 2013
PNAS Huynen

 


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