ZonMW grant for Harry Dolstra & Michel Schaap

Dolstra -Schaap

Harry Dolstra (Department of Laboratory Medicine) and Michel Schaap (Department of Hematology) received a grant of 495 k€ from ZonMW for a project entitled "Vaccination with minor histocompatibility antigen-loaded donor DC vaccines to boost graft-versus-tumor immunity after allogeneic stem cell transplantation". The objective of this phase I/II clinical study is to investigate the safety and efficacy of donor DC vaccines transfected with MiHA-encoding messenger (m)RNA and siRNA targeting PD-1 ligands to improve tumor-reactive CD8+ T cell responses after allogeneic stem cell transplantation.


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