Marks, Hendrik (4-kant)
Name:
Dr. Hendrik Marks 


Function:
Assistant Professor


Theme:



Profile

Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of the early embryo and are widely used as in vitro model to study pluripotency and embryonic development. Recent advances in stem cell technology enabled the derivation of mouse ESCs in defined serum-free medium containing 2 kinase inhibitors (2i), so-called "ground state" pluripotent ESCs.The inhibitors are thought to maintain stemness by blocking the signalling activity of Erk and Gsk3. Information on signal transduction, transcriptional networks and epigenetic mechanisms acting in ground state pluripotent cells is scarce.

The aim of my research group is to further define the ground state and to decipher regulatory mechanisms that maintain ESCs in the ground state. Current projects include: i) unravel the mode of action of the 2 kinase inhibitors in ground state pluripotency by state-of-the-art (phospho)proteomics on signalling pathways and nuclear factors; ii) decipher regulatory transcription factor networks and epigenetic mechanisms acting to maintain and to exit the ground state by genome-wide bisulfite sequencing and ChIP-seq; iii) use single cell RNA-Seq profiling to determine the role of (transcriptional) heterogeneity.

Hendrik Marks obtained his PhD from Wageningen University in genomics and transcriptomics of White Spot Syndrome Virus. In 2006 he joined the department of Molecular Biology at Radboud University Nijmegen to initiate epigenetic profiling of mouse embryonic stem cells. Recently he obtained the prestigious NWO VIDI grant to establish his own research group.


National & International Personal Prizes & Awards

  • VIDI grant from the Netherlands Organization for Scientific Research (NWO) in May 2013
  • PhD certificate of CT de Wit PE&RC Graduate School Wageningen University
  • Stichting Fonds Landbouw Export Bureau 1916/1918 travel grants

Secondary functions

None


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