Jan Smeitink

smeitink, Jan.jpeg
Prof. Jan Smeitink 

Full Professor

Mitochondrial diseases


Research interests include the study of the mitochondrial OXPHOS system in health and disease with special emphasis on the elucidation of genetic defects underlying complex I and other OXPHOS-system enzyme deficiencies. Cell lines harbouring genetic defects, and fly, fish, mice and rat models are used as human model systems to provide insights into the cellular biological consequences of such defects. Jan Smeitink goals are to enhance the understanding of human mitochondrial complex I assembly, the pathophysiological consequences of mitochondrial disease, the natural history of mitochondrial disease, the validation of clinical relevant outcome measures  and the development of new treatment strategies.

Jan Smeitink is full professor in Mitochondrial Medicine since January first 2001. Since 1996 he is director of the Radboud Center for Mitochondrial Medicine (www.rcmm.info) and Head of the Department of Metabolic Diseases of the University Medical Centre Nijmegen. In 2006 he was appointed as Foreign Adjunct Professor at the Karolinska Institutet, Stockholm, Sweden. August 2006 he received from Her Majesty the Queen the Prinses Beatrix Foundation Jubilee Award for his research on mitochondrial medicine.  From April 1 2008  - 2012 he is Director of the Institute of Genetic and Metabolic Disease (www.igmd.nl). From 2010 – 2015 he  was chairman of the Centre for Systems Biology and Bioenergetics.  Smeitink is theme leader of the Mitochondrial Disease theme and vice-chair of the Radboud Nanomedicine Initiative. Since March 2011 he is Chief Executive Officer of Khondrion (www.khondrion.com) a clinical-stage pharmaceutical spin-out of the Radboudumc.

National & International Personal Prizes & Awards

  • Prinses Beatrix Foundation Jubilee Award (2006)
  • Foreign Adjunct Professor Karolinska Institute (2006)
  • Honorary Member Pediatric Neurology Association Hong Kong (2011)
  • Elected as a member of Academia Europaea (2013)
  • Knight in the Order of the Dutch Lion (2016)

Secondary functions

Founding CEO Khondrion

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