Wiegertjes, Renske 2017.jpg
Name:
Ms. Renske Wiegertjes 


Function:
PhD Candidate


Theme:
Inflammatory diseases



Profile

My PhD project focuses on the effects of SOCS3 on TGF-β signalling in chondrocytes. During osteoarthritis (OA), disrupted TGF-β/Smad3 signalling leads to chondrocyte hypertrophy and cartilage damage. Suppressor of cytokine signalling (SOCS) 3 has been identified as a potential inhibitor of TGF-β/Smad3 signalling. Therefore, we hypothesize that SOCS3 disrupts TGF-β signalling in chondrocytes, by inhibiting Smad3 function, possibly leading to chondrocyte dysfunction and cartilage damage.


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