Regenerative medicine is a rapidly emerging field in translational medicine that aims at  extending healthy lifespan through healthy aging by developing curative therapies for diseases caused by tissue damage and ensuing organ dysfunction. These include diseases of the heart muscle and valves, skin, articular, meniscal and intervertebral cartilage, bone defects, intestine and digestive organs, central nervous system, blood and immune system and kidney. Regenerative medicine takes full advantage of contemporary developments in stem cell and molecular biology, epigenetics, genomics and proteomics and biomaterials and bioengineering, while seizing new opportunities as they emerge from advances in molecular diagnostics, imaging guided therapies for the minimally invasive treatments and novel drugs.

The theme Reconstructive and Regenerative Medicine (RRM) constitutes a centre of excellence that combines unique expertise as present at the Radboudumc in the fields of cell biology, biochemistry, immunology, tissue engineering, molecular biology, biomaterials, chemistry, transplantation biology, and clinical research. It is the leading research center in regenerative medicine in the Netherlands by focusing on top-level research related to regeneration of diseased tissues. RRM bridges the bench-to-bedside gap by unifying a large number of renowned research groups that are focusing on both basic science (e.g. chemistry, molecular biology) and clinical translation (tissue engineering, biomaterials, stem cell therapy). To this end, RRM is participating in numerous leading national and international research programs funded by Dutch, European or American funding agencies. The aim of RRMis to strengthen the already existing synergy between the various participating laboratories by stimulating interaction between clinicians, basic scientists and private partners in the Nijmegen area and develop therapies that will improve the quality of health care.